Kommu Pradeep*, Athuluri Venu1
*Scholar, Department of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur
1DCRM Pharmacy College, Inkollu.
A B S T R A C T
Transdermal patches of Keterolac solid lipid nanoparticles were prepared and evaluated. Stable nanoparticles of SLNs were prepared using high-shear homogenization followed by ultrasonication technique. 32 factorial designs were used in the process of optimization. This method was easy to apply, simple, cheap and promising for preparing nanoparticles. To study the interaction between drug and excipients DSC and FT- IR studies were performed and it was found that there was absence of interaction between drug and excipients. The drug release studies that were performed for 24hrs conferred that the drug release was by diffusion through the prepared SLNs. It can be concluded that from the obtained results Keterolac SLNs can be employed for controlled delivery of drug in the treatment as NSAIDs.
Keywords: Keterolac, Compritol 888 ATO, Precerol ATO 5 and Pluronic F127