Thursday , 20 June 2024

Preparation and evaluation of polyherbal formulation for its hepatoprotective activity against ethanol mediated paracetamol induced intoxication rat model

A. Prathyusha*, Konda Ravi Kumar1
*Department of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh.
1Hindu College of Pharmacy, Guntur

Objective: The present work was executed to evaluate the hepatoprotective potency of a polyherbal preparation. The objective of this study is to induce experimental hepatotoxicity using ethanol mediated paracetamol in normal Albino wistar rats and study the hepatoprotective activity of polyherbal formulation by comparison of changes in levels of liver parameters between normal and hepatic intoxication rats. Methods: The effect of methanol extract of poly herbal preparation containing Pods of Moringa oleifera, Fruits of Piper Longum and Seeds of Hordeum Vulgare was investigated in ethanol mediated paracetamol induced intoxication rat model. Results: Ethanol mediated Paracetamol administration caused severe hepatic damage in rats as evidenced by elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin levels and cholesterol. The selected hepatic parameters after the oral administration of 150 and 300 mg/kg b. w of poly herbal formulation was significantly lower the blood glucose levels. Conclusions: The display of synergy or antagonism by the composite herbal extracts in ameliorating liver toxicity depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations.

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