Formulation and Evaluation of Fluoxetine Fast Dissolving Tablets

Ajay Kumar A*, Haranath C
Raghavendra Institute of Pharmaceutical Education & Research, Ananthapuramu, AP, India.

Abstract
The main aim of the present study was develop and evaluate the fast dissolving tablets of Fluoxetine by direct compression method. Sodium starch glycolate, Crospovidone and Croscarmellose sodium were used as super disintegrants to achieve the desired disintegration time required for the fast dissolving tablets. To mask the bitter taste and to improve the sweetness Peppermint flavor was used. Mannitol is used as a sugar based multifunctional diluent. The prepared tablets were evaluated for their physical (hardness, friability, weight variation) and all the parameters were found to be within the limits. Organoleptic (taste, mouth-feel, color) and functional (disintegration time) properties and for the drug content. The excipients were used in different concentrations. The release in the order of super disintegrants. Crospovidone > Croscarmellose > Sodium Starch Glycolate. The maximum in vitro dissolution was found to be with formulation F4. It clearly shows due to the superdisintegrant – (Crospovidone at 5%) and it seems to be the best.
Keywords: Fluoxetine, Sodium starch glycolate, Crospovidone and Croscarmellose sodium