Prashant Patil1*, S.N.Sriharsha1, Yashwant Kumar.D1, K.S.S.N. Neelima2
1Pacific College of Pharmacy, Pacific University (PAHER), Udaipur, India
2SARC- (Scientific and Applied Research Centre) – Hyderabad
The present study was undertaken to assess the potential of Tamarind seed polysaccharide (TSP) to act as a biodegradable carrier for colon specific drug delivery. Hence an attempt was made to develop matrix tablet based formulation using TSP which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. . The matrix tablets were prepared by dry granulation technique containing different concentrations (20% mg to 120% mg Quantity per each matrix tablet) of TSP using Ibuprofen as a model drug. The matrix tablets were evaluated for different quality control tests, content uniformity and invitro drug release study. Drug release studies were carried out in 0.1M HCl, pH 6.8 Sorensen phosphate buffer (SPB) and pH 5.9 phosphate buffer saline without rat caecal content. The drug release studies were carried out for 21 hours since the usual colonic transit time is 20−30 hours. Samples, 1ml, were taken at different time intervals and volume was made up to 10 ml with SPB, filtered and absorbance was measured at 221 nm. The prepared Ibuprofen matrix tablet using various proportion of Tamarind indica gum were evaluated for drug release profile for Colon Targeted Drug Delivery System. The per cent drug release in pH 6.8 SPB was more than 0.1M HCl. The result showed that, the matrix formulation F4 released almost the entire quantity of the drug at the end of 24 h dissolution study. It appears from these results that F4 could target ibuprofen to colon.
Keywords: Colon specific drug delivery, Tamarind seed polysaccharide, Matrix tablets, Biodegradable carrier, Enzyme induction