G. Sindhu*, V. Jayashankar Reddy, T. Usha Kiran Reddy
S V U College of Pharmaceutical Sciences, S.V University, Tirupati–517502.
A B S T R A C T
The present study was aimed to explore the hepatoprotecive activity in aqueous whole plant extract of EN on rats. Acute toxicity studies were conducted in Male Wistar rats by using OECD guidelines No.423. The protective effects shown by EN with biochemical parameters (SGOT,SGPT & ALP) and histological parameters recorded with CCl4 induced hepatotoxic rat models clearly depicts that EN possessed hepatoprotective activity. The 400 mg/kg and 200mg/kg of EN treated groups showed comparable hepatoprotective activity with standard drug sylimarin. The 400 mg/kg of methanolic extract of Evolvulus nummularius treated group has better action the 200 mg/kg body weight.
Keywords: Cobicistat Darunavir, RP-HPLC, Phosphate buffer, ACN