Wednesday , 19 June 2024

Evaluation of Analgesic Activity and Anti-Epileptic Activity of Ether Leaf Extract of Guggul

K. N. S. Karthik, Konda Ravi Kumar*
Department of Pharmaceutical Chemistry, Hindu college of Pharmacy, Amaravathi Road, Guntur. Andhra Pradesh, India.

Commiphora mukul is a flowering plant in the family Burseraceae. It is a shrubor small tree, attaining maximum height of 4 m, with thin paper y bark and thorny branches. The leaves are simple or trifoliate, the leaf lets ovate, 1-5cmlong, 0.5-2.5 cm broad, irregularly toothed. Commiphora mukul is as tunted bush with spine scent branches belonging to family Burseraceae. It is commonly known as guggul (Gl) and has been a key component in ancient Indian Ayurvedic, Unani and Siddha system of medicine. Oleogumres in obtained from Commiphora mukul used for the medicinal preparation and commercially known as Indian bdellium or Guggul and the extract of this gum, called gugulipid, guggulipid or guglipid, located inducts of the soft under bark. Gugulipid is the ethyl acetate extract of gum guggul resin (raw material) that is harvested directly from the Commiphora mukul tree. Pharmacological screening includes various activities like Analgesic activity and anti-epileptic activity by using Diclofenac and Diazepam as a standards. The methods include Eddy’s hot plate method and Electro-convulsometer respectively. Commiphora mukul leaves were extracted by petroleum ether and it was isolated and purified by various spectral analysis. The spectral analysis revealed that terpenoids, steroids, flavonoids and tannins were present.
Keywords: Artemether and Lumefantrine, RP-HPLC, method development

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