Srivani*1, Venugopalaiah Penabaka2, CH. Praveen kumar3
1PG Research scholar, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Nellore, A.P.
2Asso Professor, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Nellore, A.P.
3Asso Professor, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Nellore, A.P.
A B S T R A C T
Background: Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability of a drug molecule. Aim: The aim of the work is to enhance the solubility, dissolution rate and oral bio availability of poorly soluble drug Valsartan by formulating them into Nanosuspension with poloxamer as a stabilizing agent. Methods: Preformulation involves the application of biopharmaceutical principles to the physicochemical parameters of drug substance with the goal of designing optimum drug delivery system. Preformulation yields basic knowledge necessary to develop suitable formulation. Results: The optimized Nanosuspensions were formulated as tablets and capsules to make the formulations stable and patient friendly. Valsartan Nanosuspensions were prepared by pearl milling technique using Zirconium beads as milling media and Poloxamer 407 as stabilizer. Conclusion: Based on its physicochemical and biopharmaceutical properties, Valsartan was selected as a drug candidates for developing Nanosuspension based formulations for improving the solubility and bioavailability by enhancing the rate and extent of dissolution.
Keywords: Biopharmaceutical properties, Pre formulation, Poloxamer 407, Valsartan, Nano suspensions.