Thursday , 29 July 2021

Development and Validation of a Stability Indicating Assay Method for the Determination of Sultiam in Tablet Dosage Form by RP-HPLC

A. Srikanth*, S. Mohammed Yusuf2
*Assistant Professor, Department of Pharmaceutical Analysis, Vasavi Institute of Pharmaceutical Sciences, Kadapa.
2Assistant Professor, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Ethiopia.

A  B  S  T  R A C T
A new method was developed for Stability Indicating Assay Method for the Determination of Sultiam in Tablet Dosage by using RP-HPLC method. The optimized chromatographic conditions were Hypersil ODS250X4.6mm, 5µ column, flow rate was 1ml/min, and mobile phase ratio was water: methanol 70:30 v/v and the detection wavelength was 245 nm. The retention time was found to be 5.943. The % purity of sultiam was found to be 98.8 (100%). The system suitability parameter for sultiam such as theoretical plates and tailing factor were found to be 7211 and 1.33 respectively. The correlation coefficient (R2) for Sultiam peak was found to be 1.000. The analytical method was validated according to ICH, Q2(R1). Hence the suggested RP-HPLC method can be used for routine analysis of sultiam in API and tablet dosage form.
Keywords: sultiam, RP-HPLC.

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