Saturday , 18 September 2021

Investigation for Anti-Ulcer Properties of Aqueous Extracts Prepared from the Leaves of Ocimum Sanctum in Rats

G. Ramya1, Dr. Y. Sridhar2, Dr. Gampa Vijay Kumar 3, Murali Sollu4
1,2,3,4KGR Institute of Technology and Management, Rampally (V), Kesara (M), Medchal-501301, Telangana, India.

A  B  S  T  R A C T
Stress causes an ischemic condition in the gastric mucosa by activation of parasympathetic and sympathetic nervous system it indicates vasoconstriction. It causes free radical generation.  Aspirin which is prostaglandin synthase inhibitor, it producing ulcers by preventing secretion of mucin and bicarbonate and impaired mucosal blood flow. Ranitidine is a H2 blocker which blocks the H2 receptors & inhibits the gastric acid secretion. The experimental studies an animal model confirmed the protective and curative activities of the Ocimum Sanctum against gastric ulceration compared with dose of ranitidine used as standard drug. Ocimum Sanctum of both doses 100 & 200mg/kg shows anti-ulcer activity but dose response observed at 200mg/kg and ranitidine results the similar to the plant dose. It significantly Ocimum Sanctum decreased gastric ulceration in aspirin induced model rats.
Keywords: Ocimum Sanctum, gastric ulceration.

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