Thursday , 29 February 2024

Development and Characterization: Proniosomes of Ketoconazole for the Management of Candidiasis

Akanksha Jethmal*1, Amit K Agrawal2, Archana Tiwari2
1Department of Pharmaceutics, Vedica College of B.Pharmacy, Bhopal, M.P, India
2Department of Pharmaceutics, Patel College of Pharmacy, Bhopal, M.P, India

The aim of present study was to prepare proniosomal gel for the topical drug delivery. Ketoconazole was used as proniosomal gel with sorbitol by using surfactant (span 60), Cholesterol, Lecithin. Proniosomal gel loaded with ketoconazole was prepared by slurry method. The properties of the proniosome such entrapment efficiency (%EE), Zeta potential, Microscopy and vesicle size, physical parameter of proniosomal gel were investigated. The morphology of Proniosomal gel was observed by SEM (Scanning Electron Microscopy). The drug release behaviour was studied by dialysis membrane. The results shows % entrapment efficiency of formulation L3S1D1 was found to be 96.5±2.3. Vesicle size of formulation L3S1D1   was large 8.6±0.4 with zeta potential -38.5and zeta deviation was -5.16. Stability studies results show that there were no significant changes observed in the vesicle size, drug retained of formulation at 5°C ± 3°C. It confirms that formulation L3S1D1 was stable at the end of 45 days. Ketconazole proniosomal gel in-vitro drug release was conducted for L3S1D1 formulation. The formulation was found to provide 86.25% release with a period of 4 hours.
Keywords: Proniosomes, Proniosomal gel, Ketoconazole, In-vitro cumulative % drug release, cholesterol, Antifungal

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