Amira A.Ghoneim*, Mohamed G.Assy, Enaiat K.Mohamed, Islam Ragab
Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
A B S T R A C T
Aniline was added to acylisothiocyante  to produce 1,3-thiourea derivative . Allowing compound  to react with sodium ethoxide, at room temperature resulted in thiazine cyclization affofding . Refluxing 2 in sodium ethoxide afforded the pyrimidine derivative . Cyclization of heteroallene  using phenylenediamine  afforded benzimidazolo pyrimidine derivative . enaminones of type  and compound undergo [3+3] cycloaddition producing pyridine derivative . While enaminone of type  afforded acetyl pyrimidine derivatives . Finally the reaction of compound 1 was allowed to react with aminoesrer producing thiophene derivative . The structures of the synthesized compounds have been deduced from their elemental analysis and spectral data. The synthesized compounds were screened for antibacterial and antifungal activities.
Keywords: Acylisothhiocyanate, thiazine, benzimidazole, thiophene, antifungal activities.