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Cycloaddition involving activated isothiocyanate: Synthesis and antimicrobial activities of thiazine, pyrimidine and pyridine derivatives

Amira A.Ghoneim*, Mohamed G.Assy, Enaiat K.Mohamed, Islam Ragab Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt A B S T R A C T Aniline was added to acylisothiocyante [1] to produce 1,3-thiourea derivative [2]. Allowing compound [2] to react with sodium ethoxide, at room temperature resulted in thiazine cyclization affofding [3]. Refluxing 2 in sodium ethoxide afforded the ... Read More »

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