Monday , 25 January 2021

Analytical Method development for the Estimation of Related Substances by High performance Liquid Chromatographyfor the Rimonabent (RIM) drug

Dr. K. Mukkanti1, Dr. Srinivas Jagarlapudi2, Panchumarthi Srinivas*1, A. Ravi Kumar2, P. Ramyasree2
1Research Supervisor of Centre for Environment Institute of Science and Technology (Autonomous) Jawaharlal Nehru Technological University, Hyderabad, Telangana. India-500085.

2Obvez Labs Pvt. Ltd.  Plot No. 22 & 23, ALEAP Industrial Area, Pragathi Nagar, Hyderabad, Telangana. India- 500090.

The main aim of present research work analytical method development for the estimation of related substances by high performance liquid chromatography for the Rimonabent drug.‘RIM’ is anti-obesity drug, a proper analytical method is required to separate and quantify it’s all related substances or impurities. The substances are separated by four stages. Each and every stage various trials were conducted by HPLC by using different chromatographic conditions. The developed new or improved method usually tailors existing approaches and instrumentation to the current analyte, as well as to the final needs or requirements and deciding on instrumentation to utilize in the development stage decisions regarding choice of column, mobile phase, detectors and method of quantification must be addressed.
Keywords: Rimonabent (RIM), HPLC, Mobile phase, Column, analyte, related substances.

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