Wednesday , 19 February 2020

KNOW ABOUT COENZYME Q-10

Abilash

About author: 
Abhilash A*, Prabhu Raj KJ, Gopi Krishna B, Dr. Hindustan Abdul Ahad
B. Pharmacy, Balaji College of Pharmacy, Anantapur, AP, India
* e-mail: a.abhiajay@gmail.com

Introduction:
Coenzyme Q-10 (CoQ-10) is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is used as medicine. Many people use coenzyme Q-10 for treating heart and blood vessel conditions such as congestive heart failure (CHF), chest pain (angina), high blood pressure, and heart problems linked to certain cancer drugs. It is also used for diabetes, gum disease (both taken by mouth and applied directly to the gums), breast cancer, Huntington’s disease, Parkinson’s disease, muscular dystrophy, increasing exercise tolerance, chronic fatigue syndrome (CFS), and Lyme disease.
Keywords:Congestive heart failure (CHF), chronic fatigue syndrome (CFS), Angina, Parkinson’s disease, Warfarin.
Description:
Some people also think coenzyme Q-10 might help increase energy. Some people have also used coenzyme Q-10 for strengthening the immune systems of people with HIV/AIDS, male infertility, migraine headache, and counteracting muscle pain sometimes caused by a group of cholesterol-lowering medications called “statins.” Coenzyme Q-10 has even been tried for increasing life span. By age 80, coenzyme-Q10 levels can be lower than they were at birth. Some people thought that restoring high levels of coenzyme-Q10 late in life might cause people to live longer.
Mechanism of Action:
Coenzyme Q-10 is an important vitamin-like substance required for the proper function of many organs and chemical reactions in the body. It helps provide energy to cells. Coenzyme Q-10 also seems to have antioxidant activity. People with certain diseases, such as congestive heart failure, high blood pressure, periodontal disease, Parkinson’s disease, certain muscular diseases, and AIDS, might have lower levels of coenzyme Q-10.
Uses:
Coenzyme Q-10 deficiency. The symptoms include weakness, fatigue, and seizures. Inherited or acquired disorders that limit energy production in the cells of the body (mitochondrial disorders). Improvement in symptoms is slow. Parkinson’s disease some research shows that taking coenzyme Q-10 supplements might slow decline in people with early Parkinson’s disease and improves the immune system of people with HIV/AIDS.
Side Effects:
Coenzyme Q-10 is likely safe for most adults when taken by mouth or when applied directly to the gums. Loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure.
Dosing:
For known coenzyme Q-10 deficiency: 150 mg daily. For mitochondrial disorders (mitochondrial encephalomyopathies): 150-160 mg, or 2 mg/kg/day. In some cases, doses may be gradually increased to 3000 mg per day p.o.
Conclusion:
Coenzyme Q-10 cures muscular Dystrophy, angina. Coenzyme Q-10 has even been tried for increasing life span.

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