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Tag Archives: Validation

HPLC Estimation of Vildagliptin in Bulk and Pharmaceutical Formulations

Rajkiran Kolakota*, P. Anil Naidu, Uha Rani Duppala Department of Pharmaceutical Analysis, Sri Sivani College of Pharmacy, NH-16, Chilakapalem Jn, Srikakulam-532402, AP  A B S T R A C T A simple and reproducible method was developed for Vildagliptin by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). Vildagliptin was separated on Altima C18 column (150 x 4.6mm, 5μm), using Phosphate ... Read More »

HPLC Estimation of Levofloxacin in Bulk and Pharmaceutical Formulations

Rajkiran Kolakota*, Y. Rupavathi Department of Pharmaceutical Analysis, Sri Sivani College of Pharmacy, NH-16, Chilakapalem Jn, Srikakulam-532402, A.P ABSTRACT A HPLC method was developed and validated to determine trace amounts of levofloxacin related substances & degradation products in its formulation. Separation of levofloxacin from impurity A, impurity B, impurity C and unknown degradation products was achieved on a YMC-Pack Pro ... Read More »

HPLC Estimation of Paroxetine in Bulk and Pharmaceutical Formulations

Rajkiran Kolakota*, P. Anil Naidu, Uha Rani Duppala Department of Pharmaceutical Analysis, Sri Sivani College of Pharmacy, NH-16, Chilakapalem Jn, Srikakulam-532402, AP A  B  S  T  R A C T A simple and reproducible method was developed for Paroxetine by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). Paroxetine was separated on ODS column (150 x 4.6 mm, 5μm), using Phosphate ... Read More »

Bioanalytical Method for Quantification of Torsemide in Human Urine Using LC-MS/MS

S. Satheshkumar*1, V. Muruganantham2 1Ph.D. Scholar, Department of Pharmaceutics, College of Pharmacy, Vinayaka Mission’s College of Pharmacy, Salem- 636008, Tamilnadu, India 2Professor, Department of Pharmaceutics, College of Pharmacy, Vinayaka Mission’s College of Pharmacy, Salem- 636008, Tamilnadu, India. A B S T R A C T Anaccurate and simple method was developed using high performance liquid chromatography with electron spray ionization ... Read More »

Analytical Method Development and Validation of Mupirocin and Bromelain in API and Its Dosage Form by RP-HPLC

N. Karnakar1, B.Manisha2, R. Narsimha Rao3, P. Amani4 1,2,3,4Venkateshwara Institute of Pharmaceutical Sciences, Charlapally, Nalgonda, Telangana. W. J. Pharm. Biotech., 2021, 8(1): 01-04 A B S T R A C T A new method was established for simultaneous estimation of Mupirocin and Bromelain by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Mupirocin and Bromelain by ... Read More »

RP-HPLC Method Development and Validation for Estimation of Metadoxine in API and Pharmaceutical Dosage form

R. Chaitanya*, D. Vijaya Durga, Dr. K. Padmalatha Department of Pharmaceutical Analysis, Vijaya Institute of Pharmaceutical Sciences for women, Enikepadu, Andhra Pradesh. A B S T R A C T A rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method has been developed and validated for Metadoxine, in its pure form as well as in tablet dosage ... Read More »

Development and Validation of New Analytical Method for the Simultaneous Estimation of Lisinopril and Amlodipine in Pharmaceutical Dosage Form by UV Spectrophotometry

Pavan Kumar.V*, P. Jyoshna, P. Nageena, E. Sandhya Mahalakshmi, K. Siva Kumar, A. Subha Jahnavi, A. Tharun Sai Department of Pharmaceutical Analysis, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati-517561      A B S T R A C T An elementary, valid, Speedy and decisive strategy was developed to determine Lisinopril and Amlodipine quantitatively in combined pharmaceutical dosage forms. The method was ... Read More »

Analytical Method Development and Validation for Simultaneous Estimation of Indacaterol and Glycopyrrolate in Pharmaceutical Dosage Forms by RP-HPLC

P. Devika1, P. Sowjanya2, Gampa Vijay Kumar3* 1KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 2KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. 3Professor and Head, Dept.of Pharmacy, KGR InstituteofTechnology and Management, Rampally, Kesara, Rangareddy, Telangana, India. ABSTRACT A new method was established for simultaneous estimation of Indacaterol and Glycopyrrolate by RP-HPLC method. The ... Read More »

Analytical Method Development and Validation for the Estimation of Brivaracetam in Bulk and Its Dosage Form by RP-HPLC

Patta Salomi*, S. Rama Thulasi, K. Ravindra Reddy P. Rami Reddy Memorial College of Pharmacy, Kadapa-516003, Andhra Pradesh, India ABSTRACT A simple reverse phase liquid Chromatographic method has been developed and subsequently validated for determination of Brivaracetam. The mobile composition of Potassium Dihydrogen orthophosphate (0.02M): Methanol 40:60v/v Buffer pH 6.0 adjusted with ortho phosphoric acid, waters column of C18 (250X4.6 ... Read More »

Validation of Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Pregabalin and Methylcobalamin in Formulation by QBD Approach

Aasadi Balaji*, G. Dharmamoorthy, G. Aruna, KV Nanda Kumar, P. Jaya Chandra Reddy Krishna Teja Pharmacy College, Chadalawada Nagar, Renigunta Road Tirupati-517506 ABSTRACT By considering the current regulatory requirement for an analytical method development, a simple, precise, accurate, linear and rapid Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for the simultaneous quantitative estimation of Pregabalin 75mg and Methylocobalamin 750µg ... Read More »

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