*S. Murali Krishna, Y. Padmalatha, L.K. Ravindranath, S. Chandrakala
Department of Chemistry, S.K. University, Anantapur, Andhra Pradesh, India
A B S T R A C T
Synthesis of 1,3,4 oxadiazole derivatives containing aromatic rings were synthesized by the condensation 4-amino benzohydrazide(2) with carbon disulphide in presence of ethyl alcohol. It forms 5-(4-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione(3). The maanich base reaction is reaction secondary amines treatment with formaldehyde and DMF .Finally compound (3) is on treatment with mannich base to obtained 5-(4-aminophenyl)-3-(piperidin-1-ylmethyl)-1,3,4-oxadiazole-2(3H)-thione(4).The structure of these newly synthesized compounds were characterized by 1H NMR,13CNMR ,Mass ,IR, and elemental analysis.
Keywords: 1,3,4-oxadiazole,TEA, Mannich Base, DMF, Hydrazine hydrate