Synthesis and Surface modification of Iron Oxide Nanoparticles for Drug Delivery

Author Details
M. seied Sajadi¹, F. Fathi*¹ ,N. Farhadyar^2
1Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
¹Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University, Tehran, Iran

Abstract
Surface functionalized magnetic iron oxide nanoparticles (NPs) are a kind of novel functional materials, which have been widely used in the biomedical applications such as drug delivery [1]. In order to implement the practical application, the particles must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of iron oxide NPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. In this paper  we focused on synthesis of iron nanoparticles and coating of them with PVP,SiO₂ and Au to combine drug (theophylline) and apply in drug delivery. The FT-IR, XRD, TEM and SEM and EDX indicated correctly the synthetic nanoparticles and showed drug well loaded on iron oxide nanoparticles surface.
Keywords: Iron oxide nanoparticles, PVP, silica, gold, drug delivery, theophylline

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