Tuesday , 5 March 2024

Synthesis and Screening of (E)-1-(4-(2(((Phenylamino) Methyl) amino) acetyl) phenyl)-4-(2-phenylhydrazono)-3-(Trichloromethyl)-1H-pyrazol-5(4H)-one

G.S.S. Anjaneya Vasavi, M. Uma Maheshwar Rao, S. Sreenivasulu*, M. Venu Gopal  
Department of Chemistry, R.G.M. College of Engineering Technology (Autonomous) Nandyala

A B S T R A C T
Synthesis of (E)-1-(4-(2-(((phenylamino) methyl) amino) acetyl) phenyl)-4-(2phenyl hydrazono)-3-(trichloromethyl)-1H-pyrazol-5(4H)-onewasachievedbyreactionofE-2-(4-(5-o4(2phenylhydrazono)-3-(trichloromethyl acetic acid (2)) in presence of DMF, aq NaNO3, isobutyl formamide afforded corresponding compound (3) which was subjected to mannich reaction with cyclic secondary amines such as piperidine or morphline or N-methyl piparazinein presence of formaldehyde in DMF to yield corresponding mannichbase (E)(4(2(((phenylamino)methyl)amino)acetyl)phenyl)-4-(2phenylhydrazono)-3-(trichloromethyl)-1H-pyrazol-5 (4H)-one (4) in excellent yield. The structure of these newly synthesized compounds were characterized by H1-NMR, C13-NMR, Mass and IR elemental analysis
Keywords: Pyrozolone, Mannich bases, β-lactum, urea.

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