Ramesh Chand Sharma*, Rajesh Saini, Mr. Ranjan Bairwa, Dr. Birendra shrivastav
Department of pharmaceutical sciences, Jaipur National University, SADTM Campus, Jaipur-302025. India.
E-mail: [email protected]
Lafutidine is a histamine H2 receptor antagonist, the gastro protective effect of which is related to its antisecretory activity and its ability to activate a sensory neuron-dependent mechanism of defense. The present study investigated whether intragastric administration of Lafutidine (10 and 30 mg/kg) modifies vagal afferent signalling, mucosal injury, intragastric acidity and gastric emptying after gastric acid challenge. The prepared tablets were evaluated in terms of their pre-compression parameters, physical characteristics etc. The optimized formulation was subjected to various kinetic release investigations and it has been observed that that the mechanism of drug releases was predominantly diffusion with a minor contribution from polymeric relaxation.
Key words: Intragastricacidity,Lafutidine, Rabeprazole, On demand therapy, Heartburn