Preparation and evaluation of bilayer tablets for Hypertensive patients

About author
Reddi Prashanth, Dr. Hindustan Abdul Ahad, Naresh babu G, Mohammed Ishaq B, Anil Kumar K
PG department of Industrial Pharmacy, Balaji College of Pharmacy, Anantapur, AP, India
E-mail: [email protected]

Abstract
The aim of the present work is to design bilayer tablets containing Losartan Potassium for immediate release using sodium starch glycolate as super disintegrant and Metoprolol succinate for extended release using Carbopol 71G, Hydroxy Propyl Methyl Cellulose (HPMC K100M), Xanthan gum and poly ethylene oxide as hydrophilic polymers and Kollidone as binder. The immediate layer was prepared by direct compression and extended release layer by wet granulation method. The tablets were evaluated for physiochemical properties. All the values were found to be satisfactory and were within limits with low standard deviation. In vitro release studies were carried out using USP type II paddle apparatus in phosphate buffer (pH 6.8) for 12 h as dissolution medium. The best formulation was subjected accelerated stability studies and the formulation retained its physic chemical characteristics even after stressed storage conditions
Keywords: Metoprolol succinate, Losartan Potassium, Carbopol 71G, HPMC K100M,  Kollidone, Xanthan gum.