Sunday , 3 March 2024

Pharmacological Studies on Anti diabetic Effect of Papaverine Psychosis Associated Diabetes Mellitus in Sprague-Dawley Rats

Sravani Batchu*, E. Bhavya
VISTAS Vels University, Department of Pharmacy, Pallavaram, Chennai
VISTAS Vels University, Departement of pharmaceutical Sciences, Pallavaram, Chennai

Papaverine is an opium alkaloid of the benzyl isoquinoline group, of low toxicity and non-habit forming. Presently its widest clinical use is in the treatment of conditions associated with smooth muscle spasm. Recent discovery of the high expression of PDE-10A in pancreatic islets may provide a basis for the anti diabetic activity. In this study, male Sprague dawley rats are taken and divided in to four groups viz., control, negative control, and two different doses of test drug (10mg/kg, i.p and 20mg/kg, i.p). High fat high sucrose diet for a period of 6 weeks and weekly once administration of apomorphine(1mg/kg, s.c) is used to induce diabetes and psychosis. Papaverine treatment is started on 21st day after confirmation of elevated blood glucose levels which indicates state of diabetes. The treatment period is continued till the end of the study. The behavioural parameters are evaluated by open field, locomotor activity, stereotypic behaviour and body temperature, weekly once prior to animal sacrifice. Treatment with papaverine at two different doses significantly exhibited antipsychotic and antidiabetic effects on HFHSD and Apomorphine induced rats.
Keywords: Papaverine, Apomorphine, Diabetes mellitus, Insulin Resistance, Oxidative stress, Phosphodiesterase (PDE) inhibitor

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