Jitendra Kumar Kumawat*, Punit Gupta, Hitesh Sharma
Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India
*E-mail: [email protected]
Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microspheres, nanoparticles, liposomes, etc. which modulates the release and absorption characteristics of the drug. Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesion is the most vital concept that is widely utilized in most of the novel drug delivery systems via mucosal membrane of buccal, nasal, digestive tract, etc when administered through oral, nasal or any other route. The mucoadhesive microspheres prepared by different techniques are widely used in sustained delivery of drugs with improved bioavailability and targeting efficacy. Mucoadhesive microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. Hence, uptake and consequently bioavailability of the drug is increased and frequency of dosing reduced with the result that patient compliance is improved.
Key words: Microspheres, Mucoadhesion, Mucoadhesive polymers, Bioadhesive polymers, Controlled drug delivery