Sunday , 19 May 2024

Methanol Extract of Phaleria macrocarpa (Scheff.) Boerl improved renal and liver histological changes in fructose 10% induced rats

ABOUT AUTHOR
Aprilita Rina Yanti*1, Maksum Radji2, Abdul Mun’im2, and FD Suyatna3
1Faculty of Pharmacy, University of 17 Agustus 1945 Jakarta, Jakarta Indonesia
2Faculty of Pharmacy, University of Indonesia, Depok, Indonesia
3Dept. of Pharmacology and Therapeutic, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

Abstract
Crown god [Phaleria macrocarpa (Scheff.) Boerl] is one of the medicinal plants that have been used empirically to treat various types of diseases such as cancer, heart disease, diabetes, gout, rheumatism, kidney, high blood pressure, eczema, acne, insect bites and wounds. Crown of god fruits contain flavonoids which suspected has the effect of hypoglycemic. This study investigated the effect of aethyl acetate extract crown god fruits [Phaleria macrocarpa (Scheff.) Boerl] against renal and heart damage induced by a high-fructose diet (10% v/v) in rats ad libitum for 8 weeks.  The rats  (n = 42) were divided into seven groups (of six each); normal control, negative control, captopril 10 mg/kg BW and exract methanolic  P. Marcocarpha (PM) at the dose 0 start at week 6 until week 8  and  1 g/kg BW for 8 weeks. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, i. p.).  Rats were sacrified to obain their kidney and liver for routine staining. Treatment with PM (methanolic extract)  and captopril significantly reduced diameter  of vena centralis  and reduced the glomerular hypertrophy (p<0,05)
Keywords: Methanolic Extract, [Phaleria macrocarpa (Scheff.) Boerl], renal and liver damage, fructose

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