Immunomodulatory Activity of Grewia Nervosa (Lour.) Panighrahi against Pyrogallol Induced Inmmuno Supression in Experimental Rats

Prasanthi .A*, P. Naresh Babu, B. Thanuja, K. Srilatha
Department of Pharmacology, Ratnam Institution of Pharmacy, Pidathapolur, Muthukur, Nellore, Andhra Pradesh

A B S T R A C T
Aim: Traditionally, Grewia nervosa is used for the treatment of rheumatism and tumour. Therefore, this study was designed to evaluate the immunomodulatory activity of the plant material. Method: The effect of the ethonol extract (EE) of Grewia nervosa on immunological function in rats was studied using Immunological Carban clearance test, Nutrophil adhesion and delayed-type hypersensitivity (DTH) response models. The extract was administered orally at doses of 200 and 400 mg/kg. Results: The extract exhibited immunomodulatory activity by causing a significant decrease in charcoal clearance, delayed-type hypersensitivity (DTH) response. Conclusion: Grewia nervosa showed increase in immunological parameters such as carbon clearance, neutrophil adhesion and DTH in rats.
Keywords: Grewia nervosa, immunomodulatory activity, Carban clearance, Nutrophil adhesion and Delayed-type hypersensitivity response.