Zubair Khalid labu1, Md. Saidul1*, Sirajul Islam1, Mst. Rifat Jahan1, Md. Mostafizur Rahman1, Md. Abu Jafor Arken1, Krishanu Sikder2
1World University of Bangladesh (WUB), Dhaka, Bangladesh
2Gono University (GB), Dhaka, Bangladesh
Floating Drug delivery system is designed to prolong the gastric residence time after oral administration, at a particular site and improving bioavailability. The idea of gastric retention comes from the need to localize drugs at a specific region of gastrointestinal tract (GIT) such as stomach in the body. The drugs which are poorly soluble in intestine due to alkaline pH; gastric retention may increase solubility before they are emptied. Floating dosage form can be prepared as tablets, capsules by adding suitable ingredients as well as by adding gas generating agents. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDs), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. This review also summarizes the in-vitro techniques, in vivo studies to evaluate the performance and application of floating systems.
Keywords: Floating Drug Delivery System, Floating Systems, Effervescent Systems, and Non-Effervescent