Saturday , 20 April 2024

Free Radical Scavenging Activity of Methanolic Leaf Extract of Bombax Ceiba on Streptozotocin Induced Diabetic Rats

Khan Majid Shabbir1,I. Sarath Chandiran*2, P.D. Chaudhari3 
1Research Scholar, Prist Univesity, Vallam, Thanjavur, Tamilnadu, India
2Professor, Ratnam Institute of Pharmacy, Pidathapolur, SPSR Nellore-524346, A.P, India
3Principal, Modern College of Pharmacy, Nigdi, Pune-44, Maharashtra, India.

The main objective of the study is to verify the antioxidant activity of methanolic leaf extract of Bombax ceiba by evaluating the superoxide dismutase, catalase and lipid peroxidation. Diabetes was induced experimentally in 12-hr-fasted rats by a single intraperitonial injection of streptozotocin (STZ) at a dose of 115 mg/kg. Blood samples were withdrawn from the tail vein at intervals of 30, 60, 90 and 120 min of glucose administration. The results showed that the antioxidant enzymes such as CAT, SOD and GPX were significantly (p < 0.05) decreased in diabetic rats compared to normal rats and extract treated rats exhibited significantly increased in these levels of kidney, liver and pancreas tissues respectively than untreated diabetic rats, where as inversely lipid peroxidation was lowered. The mean levels of vitamins C and E were found to be significantly increased in methanolic leaf extract of Bombax ceiba -treated diabetic rats. It may be suggested that methanolic leaf extract of Bombax ceiba confers protection against experimental diabetes through its anti hyperglycemic and antioxidant properties.
Keywords: Streptozotocin (STZ), Antioxidant, Bombax ceiba, SOD, Catalase, Lipid Peroxidation.

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