Friday , 19 July 2024

Formulation and In-vitro Evaluation of Daclatasvir Dihydrochloride Oral Dispersible Tablets

Dr. Satyanaraya Tanuku, Sravani Annapureddy, AdapaSatish Kumar, Dr. N. Dora Babu, B. Saraswathi
Mother Theresa Pharmacy College, Kothuru Village, Sathupally -507303, Khammam, Telangana, India

In the present work, an attempt has been made to develop fast disintegrating tablets of Daclatasvir dihydrochloride. In the present work Solutab, Polyplasdone XL and Explotab were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. Camphor was employed as sublimating agent, due to presence of camphor maximum pores will be formed. As the number of pores were more the body fluid will penetrates more easily. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F8 formulation showed maximum % drug release i.e., 99.23% in 30 min hence it is considered as optimized formulation. The F8 formulation contains Explotab as super disintegrate in the concentration of 20 mg. 

Keywords: Daclatasvir dihydrochloride, Sublimating agent , camphor, Solutab, PolyplasdoneXL and Explotab.

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