Katta Sridhar*, Kongi Kavya Sudha, Ballavolu Sandeep, Chirumanu Ramadevi
Swathi College of Pharmacy, Venkatachalem, Nellore, Andhra Pradesh, India
In the present research work controlled release floating matrix formulations of Diltiazem by using various concentrations of polymers sodium bi carbonate were developed. After the preformulation studies the formulation blends were subjected to evaluation tests of various precompression and post compression parameters and all the formulations were found to possess good flow properties. Among all the formulations F8 formulation showed minimum floating lag time of 2.25min and 12hrs duration of floating time which retarded the drug release up to desired time period i.e., 12 hours. The dissolution data of optimized formulation followed zero order release kinetics and the mechanism of drug release showed higuchi’s release with diffusion exponent indicating case II transport.
Keywords: Diltiazem, Ethyl cellulose, Eudragit S-100, Eudragit L-100, effervescent floating tablets.