Singh Vikas Kumar*, Pokhariyal Tarun, Tiwari Ajay Kumar
Department of Pharmaceutics,
Jaipur National University, Jaipur, Rajasthan
In the present study an attempt was made to design the matrix type transdermal patch of Mefenamic Acid (NSAIDs) with HPMC E-5 and ethyl cellulose polymer in various concentrations. Transdermal patch were formulated by solvent casting technique with different polymer proportions using Polyethylene Glycol-400 as plasticizer. The physicochemical compatibility of the drug and the polymers was carried out by Infra Red spectroscopy (FTIR). The results suggested no physicochemical incompatibility between the drug and the polymers. Blank films were prepared and evaluated for characteristics like smoothness and flexible. Further drug loaded patches were evaluated for their thickness, weight uniformity, folding endurance, percent moisture content, percent moisture uptake, surface pH, tensile strength, drug content,andin-vitrorelease study. The release profiles were found to be varied with various concentrations of HPMCE-5 and Ethylcellulose Polymer. The in-vitro release profile showed highest drug release 98.21% in 8 hours from F-1 and minimum 64.82% in 12 hours from F-2 cannot be considered as ideal formulation. The F-5 showed the release of 91.04% in 12 hours considered as ideal formulation.
Key words: NSAIDs, HPMC , Solvent Casting Technique, Plasticizer