Formulation and Evaluation of Buccal Patches of Prazosin Hydrochloride

Author Details
PokhariyalTarun*, Singh Vikas Kumar, Tiwari Ajay Kumar
Department of Pharmaceutics
Jaipur National University, Jaipur, Rajasthan
E-mail: [email protected]

Abstract
Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. Prazosin Hydrochloride patches were prepared by  usingHydroxy Propyl Methyl Cellulose E-15, Ethyl cellulose 20 cps, Poly vinyl alcohol and Poly Vinyl Pyrollidone K-30. IR and UV spectroscopic methods revealed that there is no interaction between Prazosin HCl and polymers. The patches were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behaviour, tensile strength, and surface pH. In vitro release studies of Prazosin Hcl-loaded patches in phosphate buffer (pH, 6.8) exhibited drug release in the range of 55.32 % to 97.49 % in 6 Hrs. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order equations, Higuchi and Korsmeyer-Peppas models. Good correlation among in vitro release and ex-vivo absorption of Prazosin Hydrochloride was observed.
Key words: Buccal Patch, Hypertension, Mucoadhesive polymers,HPMC