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Formulation Development and Evaluation of Emtricitabine and Tenofovir Disoproxil Fumarate Film Coated Tablets

B. Venkateswara Reddy1*, K. Navaneetha1, K. Venkata Ramana Reddy2, P. Poli Reddy3 
1Department of Pharmaceutics, St.Pauls college of Pharmacy, Turkayamjal (V), Hayathnagar (M), R.R.Dist-501510
2Department of Pharmaceutics, Sree Datta Institute of Pharmaceutical Sciences, Sheriguda (V), Ibrahimpatnam (M), R.R.Dist-510501
3Department of Pharmacology, Swami Ramananda Tirtha Institute of Pharmaceutical Sciences, Ramananda Nagar, Post S.L.B.C , Nalgonda-508004
Received: 28 April 2014, Accepted: 19 June 2014, Published Online: 18 July 2014

Abstract
The present work is aimed to formulate the film coated tablets of Emtricitabine and Tenofovir disoproxil fumarate, drugs which are used in the treatment of HIV-1 infection. Tablets are prepared by wet granulation method using the different excipients, namely Sodium starch glycolate, Di calcium phosphate, starch 1500, ideal blue, Iso propyl alcohol. FTIR studies revealed that there are no incompatibilities between drugs and polymers used. The prepared tablets are evaluated for various properties. The In-vitro dissolution profiles of the formulations were compared with the innovator product TRUVADA. All the physical parameters are found to satisfactory for the formulation T-3 and the disintegration time was found to be 8 min 50 sec. Invitro drug release profile of formulation T-3 is matching with the innovator. Thus it can be concluded that the formulation T-3 is best formulation. The study can be extended to determine the in-vivo behaviour of the tablets.
Keywords: Film coated tablets, Emtricitabine, Tenofovir disoproxil fumarate, Wet granulation, Truvada, Innovator.

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