Tuesday , 16 April 2024

Formulation and Evaluation of Osmotic Tablets of Zafirlukast

Tanguturi Jaya Harika*, Venugopalaiah Penabaka, Yerikala Ramesh
Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur  (V&P), Muthukur (M), SPSR Nellore (Dist) 524346, Andhra Pradesh, India.

In osmotic technology system a tablet containing a core of drug surrounded by a Semi permeable membrane drilled with a delivery orifice.  Once this system comes in contact with the gastrointestinal fluids, the osmotically driven water enters the system through the semi permeable membrane, dissolves the soluble agents and exits through the delivery orifice. The main aim of the present work is formulate and evaluate of osmotic tablets of Zafirlukast and the objective is to release the drug in a controlled manner. Zafirlukast is an orally administered leukotriene receptor antagonist used for the chronic treatment of asthma. While zafirlukast is generally well-tolerated, headache and stomach upset often occur. It is usually administered orally. Cellulose acetate was used semi permeable membrane. Sodium chloride act as osmogent. FTIR results revealed that there was no interaction between dug and polymers used in the formulation. The prepared osmotic tablets showed good in vitro dissolution profile showing the release of constant drug for 12 hours. The stability study revealed that the formulations were found to be stable. From this, study it can be concluded that, osmotic tablets could be prepared to improve the bioavailability of Zafirlukast.
Keywords: Zafirlukast, osmotic pressure, semi permeable membrane, delivery orifice.

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