Tuesday , 2 June 2020

Formulation and Evaluation of Oral mouth dissolving Tablets of Dapsone

B. Sireesha1, K. Sunil kumar2
1Sun Institute of Pharmaceutical Education And Research, Kakupalli, Nellore, Andhrapradesh, India.
2Associate Professor, Department of Pharmaceutics, Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.

A B S T R A C T
The aim of the present study is to formulate the Oral Mouth Dissolving tablets (ODT) of Dapsone using SSg, Crospovidone, Croscarmellose sodium and other directly compressible excepients by direct compression method. Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties. Ten  formulations of oral mouth dissolving tablets were prepared using direct compression method  with various polymers for different ratios. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and buoyancy.  The mouth disintegating tablets of Dapsone developed in this investigation releases drug within 30 minutes. Thus, we are able to achieve our objective of preparing mouth disintegrating tablets of Dapsone with minimum excipients and simple method of manufacture.
Keywords: Dapsone, Oral mouth dissolving tablets, Direct compression method, Crospovidine, Croscarmellose sodium

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