Saturday , 25 May 2024

Evaluation of Antiurolithiatic activity of Ethanolic Extract of Alphonsea Sclerocarpaon Ethylene Glycol Induced Urolithiasis in Rats

Vinitha.M*, Dr. P. Dharani Prasad, Dr. V. Jayasankar Reddy, Dr. P. Jayachandra Reddy
Department of Pharmacology, Krishna Teja College of Pharmacy, Tirupathi-517506

Kidney stones are one of the most painful of the urologic disorders. Renal stone affect 5% to 15% of adults. In the present study the roots of Alphonsea sclerocarpa Linn were used for antiurolithiatic activity. In vivo study the effect of an ethanolic root extract of M. esculenta(150 mg/kg, p.o. and 300 mg/kg, p.o.) was studied in experimentally inducedrenal stone in rats. Ethylene glycol model (0.75 % in drinking water, for 28 days) was used for renal stone induction. After completion of experimental studyblood, urine and kidney sample was used for various parameters. In preliminary phytochemical screening and TLC analysis identifies presence of saponinsand flavanoids in ethanolic extract of A. sclerocarparoots. Inethylene glycol treated animal modelethanolic extract of A. sclerocarparoots showed significant results on stone promoters (Calcium Oxalate, Inorganic Phosphate and Sodium), Kidney function parameters (Uric acid, BUN, Creatinine and LDH) and antioxidant parameters (Lipid peroxidation, catalase and glutathione).Conclusion of this investigation was ethanolic extract of A. sclerocarparoots shown promising antiurolithiatic activity and support folklore claims of theseplants as antiurolithiatic. The mechanism of action of these plants for antiurolithiatic isapparently related to increased diuresis and lowering of urinary concentrations of stoneforming constituents, though it should be confirmed by the extensive exploratory studies.
Keywords: Kidney stones, Alphonsea sclerocarpa, Ethylene glycol, anti-urolithiatic activity.

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