Hyma.P1*, Noor Jahan2, Raheemunissa3, Sreelekha G4, Babu K5.
Department of Pharmaceutics, Jyothishmathi college of Pharmacy, Hyderabad, India
Chlorpheniramine maleate belongs to the first generation alkylamine antihistaminic classification of histamine antagonists. This is a lipid soluble amine which is useful in the treatment of allergic disorders like conjunctivitis and rhinitis. The objective of the present work was to formulate and evaluate a novel topical emulgel of this antihistaminic drug i.e, Chlorpheniramine maleate. The beneficial effect of antihistaminics in atopic dermatitis is due to their antipruritic and local anaesthetic actions. Chlorpheniramine maleate is usually used, as it was proved to be non interfering with the other normal activities of the body. Carbopol, Hydroxy propyl methyl cellulose are used as polymers or gelling agent, the influence of type and concentration of them on the release of chlorpheniramine was investigated. Tween, span, propylene glycol, oleic acid were used as penetration enhancers, the effect of these on diffusion of chlorpheniramine maleate across the semi permeable membrane was tested. The optimized formulation i.e, F8, which was found to release the maximum dose of the drug, is then tested in vivo on the rat skin and observed for any allergic reactions. Results revealed that the optimized formula containing 2gm HPMC and 1gm propylene glycol was found to relieve allergic reactions compared to commercially available emulgel formulation i.e, Voltaren. So it can be concluded that topical emulgel enhanced permeation of Chlorpheniramine maleate with avoidance of GIT adverse effect.
Keywords: Chlorpheniramine maleate, Carbopol 934, HPMC, Drug content, Skin irritation studies.