Friday , 23 February 2024

Formulation and Evaluation of Niosomes containing Amoxicillin

Rituraj Kashyap*, Dev Rahul, Dr. Shashi Tripathi, U.S. Sharma
Sir Madanlal Institute of Pharmacy, Alampur, Hauj, Etawah, U.P, India-206001.

Niosomes are microscopic non-ionic surfactant vesicles which foms on self-assembling of non-ionic surfactant. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. Niosomes and liposomes both have similar physical properties but their chemical properties are different. The method of preparation of niosome is hand shaking method. A method of in-vitro release rate study includes the use of dialysis tubing. Niosomal vesicle is formed by making use of non-ionic surfactants whereas liposomal vesicles of lipids. Niosomes are known to be superior to liposomes because of their higher chemical stability of surfactants than lipids. This research article focuses on the concept of niosomes, advantages and disadvantages, composition, method of preparation, factors that influence the niosomal formulation and characterization, application of niosomes. Niosomes can be utilized in the treatment of several diseases like Psoriasis, leishmaniasis, cancer, migraine, Parkinson etc. Niosomes can be used as diagnostic aid. Various methods of niosomal administration include intramuscular, intravenous, per-oral and transdermal. Niosomal technology has been successfully used in cosmetics. Still researchers have to focus a lot on the commercial utility of niosomes in drug delivery. Formulated niosomes were evaluated for entrapment efficiency, vesicle diameter, in-vitro release.  Entrapment efficiency and drug release were markedly dependent on surfactant: cholesterol ratio and quantity of ethanol used.
Key words: Niosomes, Amoxicillin, span 80, cholesterol, Tween-80

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