Saturday , 20 July 2024

Formulation and Evaluation of Mucoadhesive Beads of Terbutaline Sulphate

N. Sowjanya*, CH. Praveen Kumar, K. Gnanaprakash
Department of Pharmaceutics, Ratnam Institute of Pharmacy, SPSR Nellore, Andhra Pradesh, India-524346
*E-mail: [email protected]

The objective of the present investigation was to formulate and evaluate mucoadhesive beads of Terbutaline sulphate to achieve substantial increase in length of stay of drug in GI tract for the treatment of asthma. Terbutaline sulphate is a β2 adrenergic receptor against which produces bronchodilation. Its short biological half life (3-4hrs) necessitates the need to be administered in three to four doses of 5mg per day. Mucoadhesive beads exhibit a prolonged residence time at the site and facilitate an intimate contact with underlying absorption surface and contributes to improved therapeutic performance of drug. In the present research work, the adhesive polymers like sodium alginate, HPMC, SCMC has been used to prepare Terbutaline sulphate mucoadhesive beads using calcium chloride(2%w/v) and aluminium chloride (2%w/v) as cross linking agents. The incorporation efficiency of prepared beads ranged between 0.199 to o.386. The effect of Bioadhesive polymers, cross linking ions were evaluated with respect to entrapment efficiency, particle size, surface characteristics and in-vitro drug release studies. Among all the formulations TBS-2 (formulated using sodium alginate (2%w/v) and HPMC(0.5%w/v) using 2%w/v calcium chloride as gellant solution) and TBS-6 (formulated using sodium alginate (2%w/v) and HPMC(0.5%w/v) using 2%w/v aluminium chloride as gellant solution) showed optimum drug release profile. Between TBS-2 and TBS-6 retarded   the drug release for 12hrs which may be due to the presence of aluminium chloride as cross linking agent. Drug release kinetics indicates that all the formulations showed linearity with respect to zero order (R2=0.990 to 0.99) as compared to first order (R2=0.751 to 0.828). The exact release mechanism was found to be super case 2 transport.
Key words: Mucoadhesive beads, bio adhesion, Terbutaline sulphate.

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