Formulation and Evaluation of Metformin Hydrochloride and Linagliptin Immediate Release Tablets

P. Ramya^*, C.S. Parameswari, B.V. Ramana, G. Nagarajan
Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India-518218

A B S T R A C T
The main objective of the work is to design and develop immediate release  tablets of Metformin Hydrochloride  and Linagliptin  in combination using different granulating agents and to perform suitable studies for the development of better therapeutic property or efficacy of drug. Ten formulations are developed by various polymers such as povidone k90,colloidal silicone dioxide, magnesium aluminium silicate, calcium  silicate, melgumine etc and other coating agents are used for better drug delivery system.The present drug delivery system is designed in such a way that  it achieves maximum therapeutic effect. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and dissolution.  Out of all the formulation developed, F10 formualtion was showing satisfactory drug release profile in comparison to innovator. Formulated tablets showed satisfactory results for various Post compression evaluation parameters like: tablet thickness, hardness, weight variation, total content uniformity and in vitro drug release.
Keywords: Metformin, Linagliptin, Immediate release, Formulation, Polymer