Design Formulation and Evaluation of Lansoprazole Mouth Dissolving Tablets

R. Kavitha*, C.S. Pasrameswari, B.V. Ramana, G. Nagarajan
Dr. K.V. Subba Reddy Institute of Pharmacy, Kurnool, Andhra Pradesh, India-518218

A B S T R A C T
The aim of the present  work is to investigate  the possibility  of preparing mouth dissolving tablet containing Lansoprazole by direct compression method. Mouth dissolving tablets are  innovative  tablet  technology  where  the  dosage form containing active pharmaceutical ingredients disintegrates rapidly, usually in a matter of seconds, without the need for water, providing optimal convenience to the patient. Lansoprazole is in the category of Proton pump inhibitors, the name itself indicates the mechanism of gastric acid HCl inhibition. Twelve  formulations  of Lansoprazole  mouth  dissolving  tablets  are  prepared  at varying concentrations of superdisintegrants are formulated. Crospovidone, Croscarmellose sodium and Sodium starch glycolate are chosen as superdisintegrants. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and dissolution. Out of all the formulation developed, formulation F8 containing of crospovidone as superdisintegrant showed better drug release of Lansoprazole. Formulated tablets showed satisfactory results for various Post compression evaluation parameters like: tablet thickness, hardness, weight variation, content uniformity and in vitro drug release.
Keywords: Lansoprazole, Mouth dissolved tablet, Formulation, Crospovidone, Croscarmellose.