Ashwini V*, Poojitha U, Surekha R, Geetha G, Srinath B
Raghavendra Institute of Pharmaceutical Education and Research, Ananthapuramu, AP, India.
The objective of this work was to prepare Glimepiride (1mg) fast dissolving tablets by wet granulation method. Glimepiride was the drug of choice because of its low dose. The prepared Glimepiride FDT were found to have faster onset of action than the conventional Glimepiride tablets. Also, they were effective in lowering fasting blood glucose levels. Glimepiride fast dissolving tablets were prepared using super disintegrants like Croscarmellose sodium, cross povidone, sodium starch glycollate by employing wet granulation technique. Prepared tablets were evaluated for angle of repose, hardness, friability, disintegration, invitro dissolution studies. Dissolution was performed using USP type II apparatus at a temperature of 37±0.5ºc, 50 RPM, 900 ml pH 6.8 phosphate buffer and samples were estimated spectrophotometrically at 228nm.The invitro dissolution studies shown that tablets prepared using cross povidone superdisintegrant showed better drug release when compared to other super disintegrants.
Keywords: Immediate release, wet granulation, Cross povidone