Amol Patil*, Sangram Madane, Rahul Adnaik, Manoj Nitalikar, Shrinivas K. Mohite
Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli 415404, MS, India
An appropriately designed controlled release drug delivery system can improve the therapeutic efficacy and safety of a drug by precise temporal and spatial placement in the body, thereby reducing both the size and number of doses required. The low bioavailability and short biological half life Cefexime following oral administration favors development of a gastro retentive formulation. Cefixime is an orally active third generation semisynthetic cephalosporin type of beta lactam antibiotic. Hence, the aim of present work was to develop a Floating tablets of to prolong gastric residence time and to increase drug absorption and hence bioavailability. 4 formulations (F1 to F4) floating tablets of Cefexime were prepared by direct compression method using cefixime with polymers like HPMC K4M and carbopol in variable concentrations. The buoyancy lag time and the total floating time was studied for all the formulations. From the preformulation studies for drug excipients compatibility it was observed that there was no compatibility problem with the excipients used in study. The drug release from the formulations follows fickian diffusion. All the formulations possessed good floating properties with total floating time between 8 – 12 hrs. Thus from the studies it can be concluded that the prepared Tablets exhibited satisfactory physicochemical characteristics and all the prepared batches showed good in vitro buoyancy. Formulations showed better control of drug release and the drug release was similar to that of marketed product.
Keywords: Cefexime, floating, HPMC K4M, carbopol