Sunday , 23 June 2024

Formulation and Evaluation of Floating Tablets of Riboflavin

Dronamraju Nirmala kumari*
Assistant Professor, Dept. of Pharmaceutics, Mother Teresa Pharmacy College, Sathuapally, Khammam, A.P, India

Gastro retentive tablets of riboflavin were formulated using different water soluble polymers like HPMC, PVP, and Carbapol of different grades and magnesium stearate and lactose were used as lubricants all the pre formulation parameters like standard curve, melting point and FT-IR studies were performed. The pre compression studies were done angle of ripose to know the flow properties of drug and polymeric mixture and calculated the bulk density and tap density to know the compresability of a powder by hausners ratio all the formulations have show good flow property. The evaluation parameters like hatdness, friability, weight variation, drug content, swelling index, percentage of drug release were studied among all the 10 formulations F5 showed the maximum drug release of 96% because of the pvp polymer was present and the optimized formula F5 was filled to various kinetic models and the results showed the F5 formulation was following the zero-order kinetics and the mechanism of drug release from F5 tablet was anamolous non-fickians diffusion 
Keywords: Riboflavin, floating drug delivery system, gastro retentive tablets, floating tablets

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