G. Archana*1, Hindustan Abdul Ahad2, P. Siva Kumar1
1Department of Pharmaceutics, Gokul Krishna College of Pharmacy, Sullurpet, Nellore, Andhra Pradesh, India
2Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
A B S T R A C T
Nizatidine is a H2 receptor antagonist used to treat gastric and duodenal ulcers and gastroesophogeal reflux disease. Fast dissolving tablets of Nizatidine offer the advantage of convenience of administration during travelling and patient compliance. The present study aims to formulate and evaluate fast dissolving tablets Nizatidine with acceptable taste and minimum disintegration time. The solid dispersions of drug with Eudragit E100 which has both taste masking and superdisintegrant properties were prepared by solvent evaporation method and spray drying method and characterized by FTIR, SEM and DSC. Fast dissolving tablets were prepared by direct compression method using prepared solid dispersions and superdisintegrants Crospovidone, Croscarmellose sodium and Soy polysaccharide in various concentrations (6%, 10% and 15%). The tablets were evaluated for hardness, wetting time, friability and disintegration time and in-vitro dissolution. The disintegration time and wetting time of the prepared tablets was found to be in the range 8.40±0.369 to 87.13±0.364sec and 6.79±1.712 to 32.46±2.488 sec. respectively. The dissolution release rates after 10min. were found to be in the range 31.51±0.74 to 68.69±0.65 for all the formulations. The formulation containing solid dispersion of drug prepared by solvent evaporation and 15% polyplasdone was found to give the best results with disintegration time of 8.40±0.369 sec.
Keywords: Nizatidine, Fast dissolving tablets, Eudragit E100, Solvent evaporation, Spray drying, Superdisintegrant.