Formulation and Evaluation of Extended Release Tablets of Guaifenesin by using Natural Polymers

Ramesh Namani*, Dr. N. Srinivas, Neeharika
Malla Reddy Institute of Pharmaceutical Sciences (MRIPS), Maisammaguda village, Dhulapally, Near Kompally, Medchal, Hyderabad.

A B S T R A C T
Exdended release drug delivery has become the standards in the modern pharmaceutical design and intensive research has been undertaken in achieving much better drug product effectiveness, reliability and safety. Guaifenesin Extended release tablets were formulated and optimized at the polymer concentration ratio of 30:20 (HPMC: EC) at the coating percentage of an average weight build-up of 7.36%w/w. In vitro release studies complied with the innovator and the formulation was found to be equal. It was increased. Similarity factor (f₂) value was calculated for all formulations. The similarity factor (f2) of all the formulations ranged from 30 to 68.7. The similarity factor of is high when comparing to other formulations so, it is more similar to that of marketed formulation.
Keywords: Guaifenesin Tablet, Manufacturing Methods, Excipients, Evaluation Methods.