Saturday , 22 June 2024

Estimation of Radioprotective Effects of Garcinia Indica Methanol Extract in Swiss Albino Mice

K. Nagendra1, Akshay Kumar R2, and H. D. Ramachandran*1
1Department of Biochemistry, Central College Campus, Bangalore University, Bangalore, India
2Research Executive, R & D Centre, Skanda Life Sciences Pvt. Ltd, Bangalore, India.

The radio protective effectiveness of methanol extract of Garcinia indica against whole body gamma radiation was premeditated in Swiss albino mice. The oral administration of Garcinia indica extract at 800 mg / kg body weight / day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 7.21 and 8.83 Gy for irradiation alone and Garcinia indica and  irradiation group, respectively, giving a dose reduction factor of 1.42. This effect of Garcinia indica as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid per oxidation assessed in the liver and the blood.
Keywords: Radioprotection / Garcinia indica, CFU-S/LD50/30, GSH, LPO, Gamma Radiation.

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