Wednesday , 22 May 2024

Formulation and Evaluation of Enalapril Oral Dispersible Tablets

M. Navya Sri*, G. Jyothsna, M. Kishore Babu
Department of Pharmaceutics, Sri Siddhartha Pharmacy College, Nuzvid, Krishna District, Andhra Pradesh-521201

The objective of the present investigation was to formulate and evaluate Enalapril oral dispersible tablets. Oral route of drug administration is most appealing route for delivery of drugs for various dosage forms. Enalapril is a angiotensin-converting enzyme (ACE) inhibitor, which is used to treatment of renovascular hypertension and symptomatic congestive heart failure. Ten oral dispersible tablets can be formulated by direct compression method by using subliming agents like menthol, camphor, and cross caramellose sodium, sodium starch glycolate, cross povidone as superdisintegrant. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and dissolution.  Out of all the formulations, the formulation F6 and process can be easily scaled up and can be easily employed in large scale production because the process is simple, cost effective and precise and also yields reproducible good results for manufacturing the tablets.
Keywords: Enalapril, Oral dispersible tablets, subliming agents, Caramellose, Formulation, Superdisintegrant

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