Evaluation of Methanolic Extract of Seed of Macuna Pruriens for Antiulcer Activity

K. Kalpana Devi¹*, Chandrika Dontha², D.S.S.N. Neelima^3
1,2Teegala Krishna Reddy College of Pharmacy, Hyderabad, Telangana State.
³Vikas Institite of Pharmaceutical Sciences, Rajahmundary.

A B S T R A C T
Ulcer is a major global problem affecting day to day life in humans and the causative factors being unavoidable such as stress, use of non steroidal antiinflammatory drugs (NSAID’s) etc. Evaluation of Methanolic Extract of Seed of Macuna Pruriens For Antiulcer Activity. In this study we observed that, methanol and extract of macuna provides significant antiulcer  effect  against  gastric  ulcers in rats. The antiulcer  activity of extracts may be a arrtributed  to their  flavanoids  content  and  antioxidant property. The extract of the plants macuna produced significant reduction in the ulcer index,  ulcer score, when compared to control. The preliminary phytochemical analysis of macuna pruriens extract showed the  presence of flavanoids, saponins  and alkaloids.
Key Words: Macuna, Anti-ulcer, flavanoids.