S. Parveen*, B. Mayuri
Department of Pharmacology, Santhiram College of Pharmacy, Nandyal, A.P
The objective is to study the antiurolithiactic activity of “Rhynchosia minima” by using ethylene glycol induced urolithiasis in male albino rats of wistarstrain.The urolithiasis was induced in rats by oral feeding of ethylene glycolated water (0.75%v/v) for 28 days ethanolic extract of “Rhynchosia minima” (200mg/kg,400mg/kg) was administered orally from 15th day for curative regimen.It was observed that the inducing agent ethylene glycol elevated the ionic parameters, calcium and phosphate levels in urine, blood urea nitrogen (BUN), serum creatinine and serum uric acid levels. Treatment with ethanolic extract of “Rhynchosia minima “significantly (p<0.001) reduced the elevated levels of ions in urine as well as BUN, serum creatinine and serum uric acid levels.The elevated calcium and phosphate levels in urine, serum creatinine, blood urea nitrogen (BUN) and uric acid levels of urolithiasis induced rats were reduced with curative regimens of plant extract treatment. The histological findings also showed improvement in kidney architecture after treatment with the plant extract. These observations enable us to conclude that the “Rhynchosia minima” has preventive properties for ethylene glycol induced urolithiasis in rats.
Keywords: Urolithiasis, caliculi, hyperoxaluria, Rhynchosia minima, antiurolithiactic activity