A Review on Serotonin Syndrome

Murugala Sravani*, Chitturi Santhiswaroopa, Jarugula Nagaraja
M A M College of Pharmacy, Kesanupalli, Narasaraopet, Guntur, Andhra Pradesh-522601

Abstract
Serotonin syndrome is a potentially dangerous syndrome that is accumulation of serotonin levels will be observed by the use of serotonergic drugs and hyperactivity of both the peripheral and central postsynaptic 5HT-1A and, most probably, 5HT-2A receptors.  A combination of mental status changes, neuromuscular hyperactivity, and autonomic hyperactivity will be observed in this syndrome. Mostly the serotonin syndrome occurs due to the therapeutic use of serotonergic drugs alone, an overdose of serotonergic drugs, or most commonly due to the drug interaction between two serotonergic drugs that work by different mechanisms. A multitude of drug combinations can result in serotonin syndrome. This review describes the presentation and treatment of serotonin syndrome and discusses the drugs and interactions that can precipitate this syndrome.
Keywords: Serotonin syndrome, neuromuscular hyperactivity, serotonergic drugs.