Saturday , 20 April 2024

Evaluation of antidepressant activity of hypericum perforatum using experimental models of depression in rats

Dr. Hareesh Dara*, D. Siva dinesh, Dr. Thatipelli Ravichander
The St John College of Pharmcy, Hasanparthy, Hanamkonda, Telangana

Depression constitutes the second-most common chronic condition in clinical practice, exceeded only by hypertension. Despite recent progress achieved in the development of clinically relevant antidepressant drugs in recent years, the currently available antidepressant therapy is not at totally effective and it is associated with many undesirable collateral effects 32-35. In addition, only 60% of patients are responsive to the treatment with the available antidepressants. For this reason, the search for new drugs for the control of the symptoms associated with depressive disorders is still desirable. In the present study, 7 days pretreatment with CR at the doses of 100, 200 and 400 mg/kg showed antidepressant activity in the forced swim test and tail suspension tests. The FST is the tool most widely used for assessing antidepressant activity preclinically. The widespread use of this model is largely a result of its ease of use, reliability across laboratories, and ability to detect a broad spectrum of antidepressant agents49. Most clinically active antidepressants are effective in the FST, while neuroleptics and anxiolytics produce different effects.34 In the forced swim test, HP significantly reduced immobility period suggesting anti-depressant activity and the activity was comparable to the reference drug IMP. Immobility is a state of lowered mood or hopelessness, which the rats experience when they are allowed to swim in a restricted space from which they cannot escape.
Keywords: Hypericum Perforatum (Hp), Antidepressant Activity

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